Table 2 Reporting adverse events for glaucoma trials (n = 79) in the ClinicalTrials.gov and the corresponding publication.

Reporting rate (n, %)

  SAEs

79 (100)

65 (82)

 < .001^a

  OAEs

79 (100)

78 (99)

.32^a

  Deaths

37 (47)

26 (33)

.07^a

AEs reported as zero (n, %)

  SAEs

20 (25)

27 (34)

.22^a

  OAEs

16 (20)

3 (4)

.001^a

  Deaths

26 (33)

18 (23)

.37^a

Number of different AEs reported per trial (median, IQR/range)

  SAEs

3 (0–8/0–74)

1 (1–4/0–23)

.22^b

  OAEs

4 (1–9/0–64)

10.5 (6–15/0–47)

.001^b

  Deaths

0 (0–0/0–4)

0 (0–1/0–5)

.37^b

Number of patients with AEs per trial (median, IQR/range)

  SAEs

2 (0–7/0–74)

2 (1–6/0–74)

.93^b

  OAEs

27 (5–95.5/0–507

53 (120.3–124.7/0–555)

.02^b

  Deaths

0 (0–0/0–4)

0 (0–1/0–5)

.53^b