Table 2 Mapping results of the proposed vasodilators, compounds 2a-j, to the generated valid pharmacophore model.

From: Synthesis of potent vasodilating agents: in silico and in vitro evaluation of 6-(4-substitutedphenyl)-3-pyridazinone derivatives as potential hydralazine analogues

Compounds

Fit value

Estimated activity (µM)

2a

5.38778

10.0398

2b

5.22513

2.87921

2c

6.3134

0.234964

2d

6.48242

0.159214

2e

6.33229

0.224963

2f

5.80112

0.764334

2g

6.31648

0.233302

2h

5.46622

1.65265

2i

6.33486

0.223631

2j

6.41419

0.186297

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