Fig. 1
From: A comparison of cognitive decline in aged mice and mice treated with aftin-4
Behavior of all the groups in the EPM test. (A) Schematic representation of the EPM apparatus with two open and two closed arms. (B) Time spent in the open arms. Males spent more time in the open arms than females did. *P < 0.05 females vs. males under all conditions as assessed using two-way ANOVA. (C) Total number of entries into the open arms in the EPM test. The control and aftin-4-treated mice entered the open arms more frequently than the aged mice did, but the difference was borderline significant (P = 0.055) according to two-way ANOVA. The data are expressed as the means ± SDs. Aftin-4 group (n = 12 females, 12 males), control group (n = 12 females, 12 males), and aged group (n = 11 females, 10 males).
