Fig. 4
From: A comparison of cognitive decline in aged mice and mice treated with aftin-4
Changes in the levels of oxidative stress markers in the cerebral cortex and blood of mice. (A) MDA levels. *P < 0.05 for aftin-4-treated mice vs. control mice by two-way ANOVA followed by Tukey’s post hoc test. Aftin-4 group (n = 12 females, 12 males), control group (n = 12 females, 12 males), and aged group (n = 11 females, 10 males). (B) SOD activity. *P < 0.05 female control mice vs. male control mice and male aged mice according to the Kruskal‒Wallis test followed by Dunn’s post hoc test. Aftin-4 group (n = 12 females, 11 males), control group (n = 11 females, 12 males), and aged group (n = 11 females, 10 males). (C) GPX activity. **P < 0.01 control females vs. control males; **P < 0.01 control females vs. aftin-4-treated males; *P < 0.05 aftin-4-treated females vs. control males; *P < 0.005 aftin-4-treated females vs. aftin-4-treated males; ****P < 0.0001 aged females vs. control males; ****P < 0.0001 aged females vs. aftin-4-treated males; *P < 0.05 aged females vs. aged males using the Kruskal‒Wallis test followed by Dunn’s post hoc test. The data are presented as medians and interquartile ranges.
