Table 1 Distance traveled (m) and average speed (cm/s) in each behavioral test. The data are presented as the means ± SDs or medians ± interquartile ranges for nonnormally distributed data.
From: A comparison of cognitive decline in aged mice and mice treated with aftin-4
Experimental groups | Statistics | Post hoc test | ||||
|---|---|---|---|---|---|---|
Test | Control (n = 24) | Aftin-4 (n = 24) *EPM test (n = 23) *SOC test (n = 23) | Aged (n = 21) | F (DFn, DFd), p value | Tukey’s or Dunn’s multiple comparisons test | |
EPM test | Distance traveled (m) | 0.82 ± 0.24 | 0.84 ± 0.27 | 0.62 ± 0.15 | F (2, 65) = 6.00 p = 0.004 | Control vs. aged p = 0.0114 Aftin-4 vs. aged p = 0.0083 |
Speed (cm/s) | 0.3 ± 0.1 | 0.3 ± 0.2 | 0.2 ± 0.0 | H (2) = 11,67 p = 0.003 | Control vs. aged p = 0.0077 Aftin-4 vs. aged p = 0.0093 | |
Y-maze test | Distance traveled (m) | 1.92 ± 0.54 | 1.84 ± 0.39 | 1.29 ± 0.26 | F (2, 66) = 14.57 p < 0.0001 | Control vs. aged p < 0.0001 Aftin-4 vs. aged p = 0.0001 |
Speed (cm/s) | 0.4 ± 0.2 | 0.4 ± 0.1 | 0.3 ± 0.1 | H (2) = 19.48 p < 0.0001 | Control vs. aged p = 0.0001 Aftin-4 vs. aged p = 0.001 | |
Three-chamber sociability test | Distance (m) | 20.90 ± 5.69 | 19.95 ± 3.35 | 17.79 ± 4.41 | F (2, 65) = 3.11 p = 0.055 | Control vs. aged p = 0.06 |
Speed (cm/s) | 3.48 ± 0.94 | 3.33 ± 0.55 | 2.967 ± 0.74 | F (2, 65) = 3.14 p = 0.049 | Control vs. aged p = 0.06 | |
Y-maze spatial recognition test | Distance traveled (m) | 1.20 ± 0.37 | 1.23 ± 0.32 | 0.84 ± 0.29 | F (2, 66) = 11.63 p < 0.0001 | Control vs. aged p = 0.0004 Aftin-4 vs. aged p = 0.0001 |
Speed (cm/s) | 0.4 ± 0.1 | 0.4 ± 0.2 | 0.3 ± 0.1 | H (3) = 15.18 p = 0.0005 | Control vs. aged p = 0.0042 Aftin-4 vs. aged p = 0.0010 | |
