Fig. 4

Identification of exclusive DEGs to 2022 MPXV infection and their relationships among metabolic processes. (A,B) Venn diagrams illustrate the shared and unique DEGs across various clades. (C,D) The X-axis represents the Z-Score, while the -log (adj p-value) is allocated to the Y-axis. The area of the bubbles is significantly proportional to the number of DEGs (C for upregulated and D for downregulated genes) associated with the given GO terms. (E,F) Pathway enrichment analysis of exclusively expressed upregulated (E) and downregulated (F) genes. The circles represent the pathway, while the lines indicate the connection among the given pathways.