Fig. 5 | Scientific Reports

Fig. 5

From: Identification of potential biomarkers for 2022 Mpox virus infection: a transcriptomic network analysis and machine learning approach

Fig. 5

Gene expression network analysis. (A & D) The assessment of the functional and physical interactions among the exclusively expressed up- and down-regulated genes. Nodes represent proteins, and edges represent the interactions among gene products. (B & E) The interconnected regions known as clusters of proteins. (A,B & D,E) The red and blue nodes indicate up- and down-regulated genes respectively, and the straight lines represent edges. (C & F) Construction of gene regulatory networks, each containing the top 10 hub genes identified from both PPI networks. (G) The heatmap delineates the expression pattern of 13 DEGs uniquely associated with infections of different clades. (H) The correlation among the 13 DEGs is shown where red and blue colors indicate positive and negative correlation respectively. LFC: Log Fold Change; NA: Not Available.

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