Table 2 Overlapping exclusive DEGs and their associated hallmark pathways.
Hallmark Pathway | Genes present | ES | FDR | |
|---|---|---|---|---|
Upregulation | Downregulation | |||
Oxidative Phosphorylation | HCCS | MPC1, OAT, ATP6AP1, POLR2F, ACO2, IDH3B, COX6A1, COX7A2, ATP5PB, COX4I1, COX7B, HADHB, MRPL11, SDHD, NDUFS3 | − 0.5761 | 0 |
E2F Targets | MTHFD2, HUS1 | POLA2, TRIP13, SMC1A, HMMR, AURKA, BIRC5, KIF4A, MCM5, CDKN3, MYBL2, CDC20, STMN1, DLGAP5, DIAPH3, KIF2C, SSRP1, BUB1B, CCNB2, NOLC1, WEE1, MCM7, RRM2, NAA38, NAP1L1 | − 0.4659 | 0.0055 |
IFN-α Response | EIF2AK2, HELZ2, TDRD7 | PSME1, PSME2, OASL, DDX60, IFI44, GBP2, B2M, ISG15 | − 0.4753 | 0.0073 |
Bile Acid Metabolism | ABCD1 | RBP1, ABCD3, PFKM, SLC35B2 | − 0.4588 | 0.0055 |
KRAS Signaling | SPHK2, DLK2, SYNPO | EDN1, SGK1, SPRR3, CDH16, KRT4, KRT15, SERPINB2 | − 0.3949 | 0.03 |
Adipogenesis | ACADS, GPAT4 | SCARB1, ACO2, COX6A1, ARL4A, COX7B, COQ3, HSPB8, NDUFS3 | − 0.389 | 0.025 |
TNF-α Signaling Via NF-κB | SLC2A3, ATP2B1, SERPINE1, VEGFA, SDC4, BHLHE40, TGIF1 | EDN1, MAP3K8, IL1A, SGK1, TNFSF9, TUBB2A, RHOB, PLK2, SERPINB2 | 0.5893 | 0.0025 |
