Fig. 1 | Scientific Reports

Fig. 1

From: Male and female behavioral variability and morphine response in C57BL/6J, DBA/2J, and their BXD progeny following chronic stress exposure

Fig. 1

C57BL/6J, DBA/2J, and BXD mice have distinct behaviors following chronic social defeat stress. (a) Experimental timeline illustrating the CSDS paradigm followed by the social interaction test (SI) and the open-field test (OFT). (b) Behavioral assessment showing the heterogeneous impact of CSDS on SI, OFT, and locomotion by genetic background in male (blue) and female (red) stressed mice. (c) CSDS-exposed male mice display distinct SI ratio, percentage of time spent in the center of the OFT, and distance traveled in the OFT in a “no-target” context amongst C57BL/6J, BXD: 5, 8, 14, 22, 29, and 32, and DBA/2J male mice following CSDS (n = 40, 6, 9, 14, 8, 6, 8, 35). (d) Same as c in CSDS-exposed female mice, C57BL/6J, BXD: 5, 8, 14, 22, 29, and 32, and DBA/2J (n = 28, 11, 12, 10, 8, 4, 14, 26). Bars represent mean ± SEM. ANOVA or Kruskal–Wallis tests followed by post-hoc comparison to C57BL/6J mice with Bonferroni correction; see Supplementary Table S1; *P < 0.05, **P < 0.01, and ***P < 0.01.

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