Fig. 2 | Scientific Reports

Fig. 2

From: Male and female behavioral variability and morphine response in C57BL/6J, DBA/2J, and their BXD progeny following chronic stress exposure

Fig. 2

C57BL/6J, DBA/2J, and BXD mice have distinct sensitivity to non-social chronic stress. (a) Experimental timeline illustrating the chronic variable stress (CVS) paradigm followed by the novelty suppress feeding test (NSF), the sucrose preference test (SP), the elevated plus-maze test (EPM), and locomotion in an open field. (b) Behavioral assessment showing the heterogeneous impact of CVS on NSF, SP, EPM, and locomotion by genetic background. Bars represent mean ± SEM for n = 6–40 mice. (c) CVS-exposed male mice display distinct latency to feed during the NSF task, SP ratio (%), time spent as percentage in open arms of the EPM, and distance traveled in an open field in the “no-target” context amongst C57BL/6J, BXD: 8, 22, and 29 and DBA/2J male mice (n = 27, 8, 9, 15, 16). (d) CVS-exposed female mice display distinct latency to feed times during the NSF task, SP ratio (%), time spent in EPM open arms, and distance traveled in an open field in “no-target” context amongst C57BL/6J, BXD: 8, 22, and 29 and DBA/2J (n = 27, 10, 9, 15, 15). Bars represent mean ± SEM. ANOVA followed by post hoc comparison to C57BL/6 J mice with Bonferroni correction; see Supplementary Table S1; *P < 0.05, **P < 0.01, and ***P < 0.01.

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