Fig. 3 | Scientific Reports

Fig. 3

From: Male and female behavioral variability and morphine response in C57BL/6J, DBA/2J, and their BXD progeny following chronic stress exposure

Fig. 3

Parental C57BL/6J and DBA/2J mice have distinct locomotor responses to acute morphine after chronic stress exposure. (a) Experimental timeline illustrating the two procedures performed, i.e. CSDS or CVS, followed by locomotor activity monitoring for 60 min in a locomotor apparatus 15 min after the animals were given an intraperitoneal injection of 7.5 mg/kg morphine. (b) Locomotor activity counts in C57BL/6J and DBA/2J male (left) and female (right) mice (n = 8) exposed to CSDS. (c) Locomotor activity counts in C57BL/6J and DBA/2J male (left) and female (right) mice (n = 8) exposed to CVS. Bars represent mean ± SEM. Unpaired t-test; see Supplementary Table S1; *P < 0.05, **P < 0.01, and ***P < 0.01.

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