Fig. 1
From: TAp73 and ΔTAp73 isoforms show cell-type specific distributions and alterations in cancer
Schematic representation of TP63 and TP73 gene structure. (A) Transcription from promoter P1 and P2 of TP63 in combination with multiple possible 3ʹ-end splice variants may give rise to at least 10 mRNAs: TAp63α, TAp63β, TAp63γ, TAp63δ, TAp63ε, ΔNp63α, ΔNp63β, ΔNp63γ, ΔNp63δ, ΔNp63ε. (B) TP73 is more complex and 5ʹ-end variability is increased by additional splice variants Ex2, Ex2/3 and ΔNʹ. Alternative initiation of translation of transcripts at the first in-frame ATG of exon 4 may also result in another set of ΔTAp73 isoforms. There are also more 3ʹ-end splice variants: α,β,γ,δ,ε,ζ,η. TA1, TA1*, TA2, sequences important for transactivation. DBD DNA binding domain, OD oligomerisation domain, SAM sterile alpha motif, ID inhibitory domain.
