Table 2 The results of reverse MR analysis of ARDS and lipids. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)

From: Causal relationship between lipidome and acute respiratory distress syndrome

Traits

Outcome

SNPs

Method

b

se

p− value

OR (95% CI)

Cholesterol

GCST90277257

28

MR Egger

0.2899

0.1131

0.0165*

1.3363 (1.0704–1.6683)

Weighted median

0.2541

0.0567

7.5881 × 10− 6****

1.2894 (1.1536–1.4412)

Inverse variance weighted

0.2268

0.0488

3.3351 × 10− 6****

1.2546 (1.1402–1.3806)

Simple mode

0.2831

0.1175

0.0230*

1.3273 (1.0541–1.6712)

Weighted mode

0.2831

0.1091

0.0151*

1.3273 (1.0716–1.6439)

Phosphatidylcholine (14:0_16:0)

GCST90277272

28

MR Egger

− 0.1363

0.1226

0.2764

0.8725 (0.6861–1.1096)

Weighted median

− 0.0581

0.0647

0.3687

0.9435 (0.8311–1.0710)

Inverse variance weighted

− 0.0178

0.0539

0.7412

0.9823 (0.8838–1.0918)

Simple mode

− 0.1233

0.1134

0.2868

0.8839 (0.7076–1.1041)

Weighted mode

− 0.1157

0.1048

0.2793

0.8907 (0.7252–1.0938)

Phosphatidylcholine (16:0_20:5)

GCST90277288

28

MR Egger

0.1628

0.3127

0.6070

1.1768 (0.6375–2.1722)

Weighted median

0.4127

0.0599

5.6037 × 10− 12****

1.5109 (1.3435–1.6991)

Inverse variance weighted

0.6216

0.1404

9.6071 × 10− 6****

1.8620 (1.4139–2.4522)

Simple mode

0.5570

0.1194

7.5325 × 10− 5****

1.7455 (1.3811–2.2061)

Weighted mode

0.5399

0.1084

3.2078 × 10− 5****

1.7159 (1.3874–2.1221)

Phosphatidylcholine (18:0_18:2)

GCST90277300

28

MR Egger

0.1993

0.2701

0.4673

1.2205 (0.7187–2.0726)

Weighted median

0.0092

0.0544

0.8644

1.0093 (0.9071–1.1230)

Inverse variance weighted

− 0.0423

0.1177

0.7190

0.9585 (0.7609–1.2074)

Simple mode

− 0.0275

0.1056

0.7960

0.9728 (0.7909–1.1965)

Weighted mode

− 0.0028

0.0982

0.9769

0.9971 (0.8225–1.2087)

Phosphatidylethanolamine (18:1_18:1)

GCST90277349

28

MR Egger

− 0.0497

0.2910

0.8656

0.9515 (0.5378–1.6832)

Weighted median

0.0020

0.0585

0.9716

1.0020 (0.8935–1.1238)

Inverse variance weighted

0.0090

0.1247

0.9421

1.0090 (0.7901–1.2886)

Simple mode

0.0516

0.1077

0.6353

1.0530 (0.8525–1.3006)

Weighted mode

0.0318

0.1136

0.7816

1.0323 (0.8262–1.2898)

Triacylglycerol (51:2)

GCST90277393

28

MR Egger

0.4669

0.1917

0.0220*

1.5950 (1.0954–2.3226)

Weighted median

0.1906

0.0627

0.0023**

1.2100 (1.0700− 1.3684)

Inverse variance weighted

0.2957

0.0835

0.0003***

1.3440 (1.1411–1.5831)

Simple mode

0.1843

0.1059

0.0931

1.2024 (0.9769− 1.4800)

Weighted mode

0.1680

0.0988

0.1003

1.1830 (0.9747–1.4358)

Triacylglycerol (52:4)

GCST90277398

28

MR Egger

0.7768

0.2001

0.0006***

2.1745 (1.4690–3.2189)

Weighted median

0.3664

0.0618

3.1784 × 10− 9****

1.4425 (1.2777–1.6285)

Inverse variance weighted

0.5341

0.0885

1.6484 × 10− 9****

1.7059 (1.4340–2.0293)

Simple mode

0.3786

0.1072

0.0015**

1.4602 (1.1834–1.8018)

Weighted mode

0.3675

0.1036

0.0014**

1.4441 (1.1787–1.7693)

Triacylglycerol (54:3)

GCST90277404

28

MR Egger

0.6220

0.2472

0.0183*

1.8628 (1.1473–3.0245)

Weighted median

0.3105

0.0621

5.7923 × 10− 7****

1.3641 (1.2077–1.5407)

Inverse variance weighted

0.3771

0.1082

0.0004***

1.4581 (1.1793–1.8028)

Simple mode

0.3632

0.1035

0.0016**

1.4379 (1.1738–1.7615)

Weighted mode

0.2484

0.0988

0.0182*

1.2819 (1.0562–1.5560)

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