Fig. 2
From: Single cell landscape of potential mechanisms in primary and metastatic hepatocellular carcinoma
Copy number variation and clonal evolution analysis of primary tumor (PT) and lymph node metastasis (LNM), portal vein metastasis (PVM) hepatocytes. (A) Phylogenetic tree of the PT sample. (B) All CNV events for the LNM sample. (C) Phylogenetic tree of the LNM sample. (D) All CNV events in PVM-derived hepatocytes. (E) Phylogenetic tree of the PVM sample. (F–G) UpSet plots showing genes shared by PT and LNM subclones on related chromosomes. (H–I) UpSet plots between PT and PVM. (J) Intra-tumor heterogeneity between PT, LNM and PVM. (K, L) PT and LNM, labeling pathways of malignant hepatocytes in PVM samples.
