Table 2 Single-nucleotide variants (SNVs) in WWOX most strongly associated with self-aware sleep duration (h) (P-valuetotal <1.00 × 10− 5).
SNV | Region | Allele (M/m) | Cohort 1 (Ansan) (N = 4,635) | Cohort 2 (Ansung) (N = 4,205) | Total (N = 8,840) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
MAF | Beta (SE) | P-valuea | MAF | Beta (SE) | P-valuea | Beta (SE) | P-valuea | pFDR | |||
rs16948804 | 16q23.1-q23.2 | G/C | 0.26 | -0.114 (0.030) | 1.37 × 10− 4 | 0.27 | -0.121 (0.034) | 3.74 × 10− 4 | -0.125 (0.024) | 1.11 × 10− 7 | 0.0182 |
rs4887991 | 16q23.1-q23.2 | A/G | 0.23 | -0.112 (0.031) | 2.77 × 10− 4 | 0.25 | -0.131 (0.034) | 1.41 × 10− 4 | -0.124 (0.024) | 2.05 × 10− 7 | 0.0182 |
rs10431970 | 16q23.1-q23.2 | C/T | 0.32 | -0.103 (0.028) | 1.79 × 10− 4 | 0.34 | -0.107 (0.032) | 8.23 × 10− 4 | -0.104 (0.022) | 2.03 × 10− 6 | 0.1188 |
rs2656620 | 16q23.1-q23.2 | C/A | 0.23 | -0.091 (0.031) | 3.36 × 10− 3 | 0.24 | -0.124 (0.035) | 3.52 × 10− 4 | -0.113 (0.024) | 2.92 × 10− 6 | 0.1188 |
rs2656621 | 16q23.1-q23.2 | G/A | 0.22 | -0.093 (0.031) | 2.60 × 10− 3 | 0.24 | -0.119 (0.035) | 6.03 × 10− 4 | -0.111 (0.024) | 4.56 × 10− 6 | 0.1188 |
rs60554456 | 16q23.1-q23.2 | G/T | 0.16 | -0.097 (0.035) | 6.24 × 10− 3 | 0.17 | -0.141 (0.040) | 3.82 × 10− 4 | -0.127 (0.028) | 4.61 × 10− 6 | 0.1188 |
rs7203648 | 16q23.1-q23.2 | T/C | 0.24 | -0.093 (0.030) | 2.27 × 10− 3 | 0.25 | -0.124 (0.034) | 2.98 × 10− 4 | -0.109 (0.024) | 5.19 × 10− 6 | 0.1188 |
rs2656619 | 16q23.1-q23.2 | G/A | 0.22 | -0.093 (0.031) | 2.74 × 10− 3 | 0.24 | -0.119 (0.035) | 6.03 × 10− 4 | -0.109 (0.024) | 5.91 × 10− 6 | 0.1188 |
rs2656618 | 16q23.1-q23.2 | G/T | 0.23 | -0.089 (0.031) | 3.72 × 10− 3 | 0.25 | -0.124 (0.034) | 3.35 × 10− 4 | -0.109 (0.024) | 6.03 × 10− 6 | 0.1188 |
