Table 3 Association of sleep parameters with single-nucleotide variants (SNVs) in WWOX gene through meta-analysis (pFDR < 0.05).

From: Genome-wide identification and functional validation of the WW domain containing oxidoreductase gene associated with sleep duration

SNV

Region

Allele (M/m)

Major homozygous group (MM)

Heterozygous group (Mm)

Minor homozygous group (mm)

 

Beta (SE)

P-valuea

Beta (SE)

P-valuea

Self-aware sleep duration (h)

 rs16948804

16q23.1-q23.2

G/C

Reference

-0.131 (0.030)

< 0.001

-0.209 (0.060)

< 0.001

 rs4887991

16q23.1-q23.2

A/G

Reference

-0.078 (0.030)

0.009

-0.304 (0.063)

< 0.001

Time in bed (h)

 rs16948804

16q23.1-q23.2

G/C

Reference

-0.113 (0.030)

< 0.001

-0.149 (0.060)

0.01

 rs4887991

16q23.1-q23.2

A/G

Reference

-0.071 (0.030)

0.02

-0.260 (0.063)

< 0.001

Habitual sleep efficiency (%)

 rs16948804

16q23.1-q23.2

G/C

Reference

-0.346 (0.280)

0.22

-0.840 (0.569)

0.14

 rs4887991

16q23.1-q23.2

A/G

Reference

-0.280 (0.283)

0.32

-0.770 (0.594)

0.20

Epworth sleepiness scale score

 rs16948804

16q23.1-q23.2

G/C

Reference

0.138 (0.091)

0.13

-0.074 (0.184)

0.69

 rs4887991

16q23.1-q23.2

A/G

Reference

0.167 (0.092)

0.07

0.107 (0.193)

0.58

  1. M, major allele; m, minor allele; pFDR, P-value adjusted for false discovery rate.
  2. a P-values are based on linear regression analysis of sleep parameters adjusted for age, sex, area, occupation, and principal components (PCs, PC1 to PC10).
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