Fig. 7 | Scientific Reports

Fig. 7

From: Bone marrow mesenchymal stem cells modulate miR-202-3p to suppress neuronal apoptosis following spinal cord injury through autophagy activation via the AMPK, MAPK, and PI3K/AKT/mTOR signaling pathway

Fig. 7

BMMSCs promote autophagy by regulating the AMPK, MAPK, and PI3K/AKT/mTOR/TFEB signaling pathway to improve functional recuperation following SCI. (A, B) Western blotting and quantitative analyses showed that BMMSCs promoted p-AMPK expression in tissue of the spinal cord. (C, D) Western blot analysis, coupled with quantitative assessment, demonstrated that BMMSCs induced increased expression of phosphorylated forms of JNK (p-JNK), Erk (p-Erk), and P38 (p-P38) in spinal cord tissue. (E, F) Western blotting and quantitative analyses showed that BMMSCs inhibited p-PI3K and p-AKT expression in tissue of the spinal cord. (G–J) Western blotting and quantitative analyses showed that BMMSCs inhibited p-mTOR expression and promoted TFEB expression in spinal cord tissue.

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