Table 4 Comparison results of modified bone char with other catalysts for synthesis of 6-Amino-5-Cyano-4-(4Chloro)-Phenyl-2-Mercapto pyrimidine.

From: Highly efficient synthesis of pyrimidine-5-carbonitrile derivatives over a robust biowaste bone char-Bronsted solid acid catalyst

Entry

Condition

Time (h)

Yield (%)

Ref.

1

NH4Cl (ammonium chloride) (0.12 g), 110 °C, solvent free

4

81

44

2

Con. hydrochloric acid (0.3 ml), EtOH, Reflux

4

51

45

3

Sodium acetate (0.082 g), water, reflux

3.5

76

46

4

Phosphorus Pentoxide (0.05 g), EtOH, Reflux

1

92

47

5

CdFe2(C4H4O6)3.5H2O (0.02 g), EtOH, Reflux

45 min

92

48

6

Modified bone char (sulfonated bonchar) (0.05 g), 80 °C, solvent free

20 min

95

This work

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