Fig. 7

Expression levels of circulating miRNAs (miR-99b-5p, miR-101-3p, and miR-431-5p) in RA patients categorized by disease duration. miR-99b-5p (Left): Expression is highest in patients with disease duration of 1–5 years, decreasing significantly in those with 5–10 years, and even more in those with over 10 years. miR-101-3p (Middle): Shows a similar trend, with the highest expression in the 1–5 years group and decreasing levels in the subsequent groups. miR-431-5p (Right): Exhibits higher expression in the 1-5- and 5-10-years groups compared to those with more than 10 years.