Fig. 5

Addiction-like measures. Cued-conflict preference as assessed on the Y-maze task prior to operant ethanol self-administration (A). Highest response requirement completed by rats on the progressive ratio task (B). Active lever presses (C) and number of ethanol reinforcers delivered (D) by minute during the progressive ratio task. Active lever presses across 4 extinction sessions, expressed as a percent of average lever presses during training (E). Ethanol consumption (g/kg) across 5 levels of footshock expressed as a percent of average consumption during training (F). Inset, summed scores across extinction (E) and footshock (F) sessions). * p < .05, *** p < .001. # indicates a female score significantly greater than a male score as determined by post-hoc testing to follow up on a sex by bin interaction. All data expressed are mean ± SEM.