Fig. 6

Effect of minipubertal treatment on locomotor activity and anxiety-like behavior. A-D. Locomotor activity was monitored in a circular corridor during 2 h. The activity monitored every 20 min (A, C) or cumulative activity (B, D) are presented for females treated with the vehicle (Veh) and Ganirelix (G) groups in Experiment 1, and flutamide (F) alone, letrozole alone or both flutamide and letrozole (F/L) in Experiment 2. E-K. Anxiety-like behavior was assessed in a 0-maze during 9 min (E). The latency to the first entry into the open arm (F, I), the number of entries into the open arm (G, J) and the time spent into the open arm (H, K) are indicated. Data are presented as means ± S.E.M. (n = 12–15 per treatment for Experiment 1; n = 10–13 per treatment for Experiment 2) *p < 0.05 for the indicated groups.