Fig. 8

Relative expression level of miR-221-3p and miR-222-3p in liver tissues of all groups, measured by quantitative polymerase chain reaction (qPCR). Normal: Mice without treatment; EAC: Ehrlich ascites-bearing mice without treatment; EAC + DOX: EAC-bearing mice treated with doxorubicin; EAC + SME: EAC-bearing mice with S. maxima extract treatment; EAC + SNE: EAC-bearing mice treated with silica nanoemulsion (SNE); EAC + SMNEC1: EAC-bearing mice treated with S. maxima extract nanoemulsion (SMNE) at 3225 µg/mL; EAC + SMNEC2: EAC-bearing mice treated with SMNE at 6451 µg/mL; EAC + SMNEC3: EAC-bearing mice treated with SMNE at 9677 µg/mL.