Table 2 Correlations between 12 biomarkers and traditional lupus nephritis activity markers in the baseline.

From: Exploring potential multiple molecular biomarkers that predict treatment response in patients with lupus nephritis

 

eGFR

C3

C4

SLEDAI

rSLEDAI

Proteinuria

Renal AI

Renal CI

Anti-dsDNA

Serum ρ

Urine ρ

Serum ρ

Urine ρ

Serum ρ

Urine ρ

Serum ρ

Urine ρ

Serum ρ

Urine ρ

Serum ρ

Urine ρ

Serum ρ

Urine ρ

Serum ρ

Urine ρ

Serum ρ

Urine ρ

MCP-1

 

− 0.29*

  

− 0.25*

− 0.27*

 

0.36**

 

0.45***

 

0.46***

 

0.49***

    

IP-10

   

− 0.28*

 

− 0.25*

       

0.44***

   

0.30*

IFN-γ

        

0.30*

  

0.24*

      

IL-6

 

− 0.31*

         

0.47***

 

0.27*

 

0.26*

  

IL-16

 

− 0.28*

     

0.30*

 

0.47***

 

0.39**

 

0.25*

    

IL-17

         

0.26*

 

0.37**

      

IL-23

       

0.33**

 

0.34**

        

TNF-RII

− 0.30*

  

− 0.25*

 

− 0.30*

      

0.38**

     

VCAM-1

 

− 0.27*

     

0.30*

 

0.37**

 

0.41***

      

RBP-4

 

− 0.30*

                

VDBP

 

− 0.41***

         

0.62***

 

0.35**

    

NGAL

− 0.28*

      

0.35**

 

0.53***

 

0.47***

 

0.34**

    
  1. MCP-1 monocyte chemoattractant protein-1, IP-10 interferon-gamma inducible protein-10, IFN-γ interferon-gamma, IL-6 interleukin-6, IL-16 interleukin-16, IL-17 interleukin-17, IL-23 interleukin-23, TNF-RII tumor necrosis factor receptor II, VCAM-1 vascular cell adhesion molecule-1, RBP4 retinol binding protein 4, VDBP vitamin D binding protein, NGAL neutrophil gelatinase-associated lipocalin, ρ Spearman’s rank correlation coefficient, eGFR estimated glomerular filtration rate, C3 complement 3, C4 complement 4, SLEDAI systemic lupus erythematosus disease activity index, rSLEDAI renal domain score of SLEDAI, AI activity index, CI chronicity index, Anti-dsDNA anti-double-stranded deoxyribonucleic acid titer.
  2. *p-value ≤ 0.05, **p-value ≤ 0.01, ***p-value ≤ 0.001.
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