Table 4 Top salient genes identified by XGDP when predicting drug responses for Dasatinib, Erlotinib and Ponatinib.
From: Drug discovery and mechanism prediction with explainable graph neural networks
Drug | Gene | Rank | Saliency score |
|---|---|---|---|
Afatinib | ERBB3 | 60 | 0.29 |
Afatinib | EGFR | 78 | 0.26 |
Afatinib | ERBB2 | 108 | 0.23 |
Imatinib | MYC | 2 | 0.85 |
Imatinib | SFN | 10 | 0.64 |
Imatinib | DDR1 | 16 | 0.56 |
Imatinib | CDKN2A | 23 | 0.54 |
Imatinib | EGFR | 31 | 0.47 |
Imatinib | IKZF1 | 93 | 0.28 |
Imatinib | SMAD3 | 166 | 0.22 |
Sunitinib | NOS3 | 7 | 0.7 |
Sunitinib | EGFR | 19 | 0.51 |
Sunitinib | FGFR2 | 47 | 0.36 |
Sunitinib | HMOX1 | 76 | 0.3 |
Sunitinib | PDGFA | 113 | 0.27 |
Sunitinib | ERBB2 | 198 | 0.19 |
