Table 3 Comparison of parameter values obtained from chimpanzee9 and mice ODE models.
Parameter description [units] | Chimpanzees | Humanized Mice (Table 1) | Source |
---|---|---|---|
Inoculation quantity [copies] | ≤ 1170 HCV RNA copies as described in [19]* | 1 × 106 | Experimental design |
Viral clearance from circulation (range), c [1/day] | Fixed** to 6.0 | 20.6–22.2 | Math modeling |
Time (range) p.i. of blocking of viral production, tir [days] | 5.3–15.5 | 1.7–3.5 | Math modeling |
Efficacy (range) of blocking of viral production, ε [%] | 85–95 | 91–95 | Math modeling |
Viral production (range), p [virions/cell/day] | 0.1–317 | 188–585 | Math modeling |
Infection rate (range), β(m) [mL/virions/day] | 0.1–11 × 10− 7 | 0.8–22.5 × 10− 11 | Math modeling |
Number of susceptible hepatocytes, T0 [cells/mL] | Fixed& to 1.87 × 106, 1.87 × 107 or 1.87 × 108 | Fixed to 3 × 108 | Math modeling |
Mean ± SD plateau HCV RNA concentration [Log copies/mL] | 6.1 ± 0.5 | 8.5 ± 0.17 | Experimental observation |
Time (range) to reach plateau [days] | 28–56 | 12–22 | Experimental observation |