Table 3 Comparison of parameter values obtained from chimpanzee9 and mice ODE models.

From: Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies

Parameter description [units]

Chimpanzees

Humanized Mice

(Table 1)

Source

Inoculation quantity

[copies]

≤ 1170 HCV RNA copies as described in [19]*

1 × 106

Experimental design

Viral clearance from circulation (range), c [1/day]

Fixed** to 6.0

20.6–22.2

Math modeling

Time (range) p.i. of blocking of viral production, tir

[days]

5.3–15.5

1.7–3.5

Math modeling

Efficacy (range) of blocking of viral production, ε [%]

85–95

91–95

Math modeling

Viral production (range), p

[virions/cell/day]

0.1–317

188–585

Math modeling

Infection rate (range), β(m)

[mL/virions/day]

0.1–11 × 10− 7

0.8–22.5 × 10− 11

Math modeling

Number of susceptible hepatocytes, T0 [cells/mL]

Fixed& to 1.87 × 106, 1.87 × 107 or 1.87 × 108

Fixed to 3 × 108

Math modeling

Mean ± SD plateau HCV RNA concentration [Log copies/mL]

6.1 ± 0.5

8.5 ± 0.17

Experimental observation

Time (range) to reach plateau [days]

28–56

12–22

Experimental observation

  1. *, Briefly, 7 chimpanzees were infected by acute-phase plasma from another chimpanzee with 1170 (n = 6) and 39 (n = 1) HCV RNA copies. Three chimpanzees were infected with an estimated range of 0.01–40 H77-RNA (genotype 1a) copies into the liver. Two chimpanzees received more than 1170 RNA copies, one received 3000 µg and a second received 22 µg of in vitro transcribed RNA. **, Could not be estimated therefore was fixed based on previous literature. &, Due to the uncertain number of susceptible hepatocytes in the liver a range of initial hepatocyte count was used. SD, Standard deviation.