Fig. 2 | Scientific Reports

Fig. 2

From: Orthotopic meningioma rat model exhibits morphological and immunohistochemical congruency and epigenetic concordance with benign primary patient-derived tumors

Fig. 2

Implantation validation. Validation of cell implantation after one week in two animals – one from each group of MO-4. The skull base implantation showed diffusely aligned tumor cells along the cannula tract, scarce cytoplasmatic staining reaction for EMA, and negative nuclei staining reaction for PR. There were no cells present on the ventral side of the brain (injection site). The convexity implantation 2 mm below the top of the skull showed viable cells but again with scarce cytoplasmatic staining reaction for EMA and negative nuclear staining for PR alongside a cystic formation probably due to a perioperative lesion. OV: Overview, HE: Hematoxylin and Eosin, EMA: Epithelial membrane antigen, PR: Progesterone receptor. Black bars 2,5 mm for OV and 100 \(\:\mu\:\)m for HE, EMA and PR.

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