Fig. 8 | Scientific Reports

Fig. 8

From: Orthotopic meningioma rat model exhibits morphological and immunohistochemical congruency and epigenetic concordance with benign primary patient-derived tumors

Fig. 8

Heatmap and correlation plots. (A) The heatmap contains the 2000 most variant CpG sites (unsupervised). It displays primary tumors (Purple bars) and corresponding xenografts (Green bars). The unsupervised clustering was performed with 200x bootstrap. It placed MO-27 primary tumor and xenograft together in one branch and pooled the remaining tumors and xenografts together. Here, however, the primary tumors (edge 1) and xenografts (edge 2) were more alike based on the top 2000 most variant CpG sites. The bootstrap shows robust and significant values for Edge 1 and 2 AU/BP (approximately unbiased/bootstrap probability) 100/100 and robust, but not significant for edge 4 and 3 AU/BP 90/95 and 89/95 respectively. (B) Correlation plots for the three sample pairs focusing on the CpGs relevant for the v12.5 BrainClassifier showed high correlations (MO-4 (R = 0.86), MO-25 (R = 0.82), and MO-27 (R = 0.93)).

Back to article page