Table 2 Overview of tumor subtype, tumor take rate, and tumor size.

From: Orthotopic meningioma rat model exhibits morphological and immunohistochemical congruency and epigenetic concordance with benign primary patient-derived tumors

Sample

Xenograft subtype match

Skull base xenografts

Convexity xenografts

P-values

Tumor take rate

Tumor sizes

mm3 (median (IQR))

Tumor take rate

Tumor sizes

mm3 (median (IQR))

TTR

Size

MO-4

Transitional

1/8 (12.5%)

0.059 (NA)

8/9 (89%)

0.26 (0.12–1.41)

0.003

NA

MO-12

Microcystic**

2/10 (20%)

0.018 (0.015–0.021)

3/10 (30%)

0.17 (0.048–0.27)

0.99*

0.20*

MO-25

Transitional/meningothelial***

3/10 (30%)

0.26 (0.19–0.31)

7/10 (70%)

0.18 (0.13–0.56)

0.18*

0.38*

MO-27

Meningothelial/Fibrous****

5/10 (50%)

0.34 (0.19–1.08)

9/10 (90%)

2.42 (0.17–2.65)

0.14*

0.61*

  1. Data are median and IQR (interquartile range). Mann-Whitney U unpaired tests were performed on both tumor take rate (TTR) and tumor size, comparing deep vs. superficial implantation. *Not significant. **Microcystic elements in larger tumors (2/5 tumors too small to ascertain). ***Largely with transitional elements, 60% of tumors displayed primarily meningothelial subtype. ****Fibrous subtype was less apparent – Meningothelial pattern in primary tumor present in most of the samples (9/14). NA: Not applicable.
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