Table1 MR results for the relationship between 8 genes on AD.

From: Integrated analyses of Mendelian randomization, eQTL, and single-cell transcriptome identify CCN3 as a potential biomarker in aortic dissection

Exposures

Outcomes

No. of SNPs

Method

OR (95%CI)

P

Heterogeneity test

Pleiotropy test

Q

P

P intercept

CCN3

AD

11

Weighted median

0.644 (0.458–0.905)

0.011

  

0.449

   

IVW

0.773 (0.603–0.991)

0.043

6.439

0.777

 
   

MR Egger

  

5.813

0.758

 

DBNL

AD

3

Weighted median

1.291 (1.011–1.649)

0.041

  

0.582

   

IVW

1.324 (1.045–1.678)

0.020

0.897

0.639

 
   

MR Egger

  

0.304

0.581

 

NPC2

AD

4

Weighted median

1.405 (1.093–1.805)

0.008

  

0.617

   

IVW

1.393 (1.096–1.769)

0.007

2.660

0.447

 
   

MR Egger

  

2.270

0.321

 

PRKCSH

AD

3

Weighted median

0.648 (0.422–0.994)

0.047

  

0.647

   

IVW

0.597 (0.374–0.953)

0.031

2.782

0.249

 
   

MR Egger

  

2.011

0.156

 

SUMF2

AD

3

Weighted median

1.351 (1.086–1.680)

0.007

  

0.804

   

IVW

1.356 (1.094–1.681)

0.005

0.133

0.936

 
   

MR Egger

  

0.032

0.858

 

TEX264

AD

3

Weighted median

0.551 (0.367–0.828)

0.004

  

0.792

   

IVW

0.552 (0.374–0.813)

0.003

1.252

0.535

 
   

MR Egger

  

1.123

0.289

 

TFPI

AD

3

Weighted median

2.280 (1.145–4.541)

0.019

  

0.842

   

IVW

2.161 (1.188–3.930)

0.012

0.287

0.866

 
   

MR Egger

  

0.222

0.637

 

TGFBR3

AD

4

Weighted median

0.611 (0.349–1.069)

0.084

  

0.920

   

IVW

0.611 (0.379–0.985)

0.043

0.059

0.996

 
   

MR Egger

  

0.046

0.977

 
  1. AD aortic dissection, IVW inverse variance weighted, OR odds ratio, CI confidence interval, P P-value, Q Cochran’s Q statistic.
Back to article page