Fig. 8
(a) and (c) Examples of signals recorded at two different ventricular sites in scarred (a) and healthy tissue (c; 27 mm from the edge of scarred tissue based on histology) when treated with the same PFA dose (1500 V, 8 trains) in the same animal and shown for three different time points (pre-ablation, 30 s post-ablation and 3.5 min post-ablation). (b) Magnified depolarization component of bipolar signals (top: before ablation; bottom: 30 s after ablation). (d) Absolute COI measured at three different time points (pre-ablation, 30 s post-ablation and 5 min post-ablation) grouped by the targeted tissue type (scar, border, healthy). An LME model of the form COI ~ Time * Tissue + (1|Pig/Lesion) revealed significant difference between border & scar, averaged over all time points (* p = 0.01). (e) Normalized COI (5 min post-ablation values normalized to 30 s post-ablation values). No statistically significant differences between the tissue types were observed using a model of the form relative COI ~ Tissue + (1|PigID). (f) Comparison of absolute COI values (pre-ablation, 30s post-ablation, and 5 min post-ablation) in healthy myocardium of healthy and infarcted animals. An LME model of the form COI ~ Time + Pig Model + (1|PigID/Lesion) revealed significant changes in COI with time post-ablation (p < 0.0001 for both post-ablation measurements compared to pre-ablation; p = 0.02 comparing 30 s and 5 min post-ablation measurements). No significant difference was detected between healthy and infarcted animals.
