Fig. 2 | Scientific Reports

Fig. 2

From: Shared rare genetic variants in multiplex autism families suggest a social memory gene under selection

Fig. 2

Selection of target genes associated with ASD. (A) Density plot for the evolutionary scores. The average number of evolutionary sequence divergence sites around the SRVs is marked for each gene. (B) Gene prioritization by evolutionary scores. Top 100 genes selected from (A) are plotted, according to the degree of normalized SRVs frequency and haplotype homozygosity. (C) Tissue specificity for the expression of target genes. Gene expression heatmaps are constructed with GTEX v8 (54 human tissue type). Gene expression values represent the Z-score normalized across the tissue type per gene. ASD, autism spectrum disorder; SRV, shared rare variant.

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