Fig. 3
Evolutionary analysis of the FRRS1L region. Evolutionary genetic analysis for 63 SRVs in FRRS1L. In the shared rare variants track below, each bar indicates 63 SRVs, and the different colors indicate the number of evolutionary sequence divergence sites at + /- 10 bp windows around the SRVs (gray = 0, orange = 1, and red > 2). In the human-specific fixed sequence track below, the red bar indicates the position of the human-specific sequence at + /- 10 bp windows around the SRVs. In the iHS track below, the single-nucleotide polymorphism with |iHS|> 2 (rs2176692) is highlighted in red. Tajima’s D and nucleotide diversity (π) were obtained using 1-kb sliding windows. The dots indicate the values corresponding to the fixed sites with the one indicating positive selection highlighted in red. SRV, shared rare variant; iHS, integrated Haplotype Score.
