Fig. 7 | Scientific Reports

Fig. 7

From: Shared rare genetic variants in multiplex autism families suggest a social memory gene under selection

Fig. 7

Improved retention of social memory in the Frrs1lh/m mice. (A) Experimental procedures of the social memory assessments. (B,C) Results of the 7d memory tests. (B) Wildtype mice exhibited comparable investigation duration between the first and second exposure to the stimulus mouse (n = 11, WT; n = 14, Frrs1lh/m; t (10) = 0.0677, P = 0.9474, q = 0.4784, multiple paired t-tests with FDR correction). (C) Frrs1lh/m mice exhibited reduced investigation duration during the second exposure compared to the first exposure (t (13) = 3.066, P = 0.0090, q = 0.0061, multiple paired t-tests with FDR correction). (D,E) Results of the 1d memory tests. Bothe wildtype and Frrs1lh/m mice exhibited reduced investigation duration during the second exposure compared to the first exposure: (D) WT mice (t (10) = 5.810, P = 0.0002, q = 0.0003, multiple paired t-tests with FDR correction), (E) Frrs1lh/m mice (t (13) = 3.832, P = 0.0021, q = 0.0021, multiple paired t-tests with FDR correction). q-value is FDR-adjusted P-value. Data are presented as mean \(\pm\) s.e.m.

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