Fig. 3
From: Role of P2 X7 receptor during focused ultrasound induced blood brain barrier modulation
Regulation of BBB-related proteins after LiFUS stimulation. (a,b) Western blot and RT-PCR results for ZO-1. The bar graph shows the normalized level of the receptors relative to that of control. Band intensity images for each group are included. # p < 0.05, ## p < 0.01, ### p < 0.001; compared to Con, ††† p < 0.001; compared to 24 h. (c,d) Western blot and RT-PCR results for occludin. The analysis method employed for occludin was the same as that for ZO-1. # p < 0.05, ## p < 0.01, ### p < 0.001; compared to Con, ††† p < 0.001; compared to 24 h. All data are presented as mean ± SD (n = 5). One-way ANOVA with Tukey’s multiple comparison test was performed. (e) Representative IHC images of DAPI (blue) and MMP-9 (white arrow, green) in the hippocampal region of the brain after LiFUS. Scale bar: 100 μm.
