Fig. 4
Tof@BSA-Chs-CP NPs alleviated pathological lesions of DSS-induced colitis. (A) Experimental design showing treatment protocols for each group: NC (no treatment), DSS (DSS-induced colitis without therapy), Tof (free Tof treatment), @BSA-Chs-CP (@BSA-Chs-CP treatment), and NPs (Tof@BSA-Chs-CP NPs treatment). The body weight (B) and DAI scores (D) change during the experiment. (C) The statistical analysis for colon length. (E) The colon sections were stained with H&E and alcian blue. Plotting scale = 100 μm. The concentrations of TNF-α (F), IL-1β (G), IL-6 (H) and IL-10 (I) in serum. n = 6. NC compared with the DSS group, #P < 0.05, ##P < 0.01, ###P < 0.001. NPs compare with DSS group, *P < 0.05, **P < 0.01; ***P < 0.001.
