Fig. 5 | Scientific Reports

Fig. 5

From: Oral colon-targeted responsive chitosan/pectin-based nanoparticles propels the application of tofacitinib in colitis therapy

Fig. 5

Effect of Tof@BSA-Chs-CP NPs on Treg/Th17 cell balance in colitis tissue. Representative flow cytometry images of Th17 (CD4+) (A) and Treg (CD25+) cells (C) in three groups. Percentage of Th17 cells (B) and Treg cells (D). The relative changes of IL-17 A (E) and IL-10 (F) gene expression. (G) Network map of genes and signaling pathways associated with IL-17 and IL-10. NC compare with the DSS group, #P < 0.05, ##P < 0.01, ###P < 0.001. NPs compare with DSS group, *P < 0.05, **P < 0.01; ***P < 0.001.

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