Fig. 3 | Scientific Reports

Fig. 3

From: Global proteomics and affinity mass spectrometry analysis of human Schwann cells indicates that variation in and loss of neurofibromin (NF1) alters protein expression and cellular and mitochondrial metabolism

Fig. 3

GO pathways for WT cDNA and Variant cDNA (global proteomics) A-D) Top 15 Gene Ontology biological pathways predicted to be altered between each NF1 variant and WT Nf1 cDNA expressing cells. The x-axis represents fold enhancement, and the FDR is represented with a heatmap. E) Top selected IPA pathways for each variant compared to WT NF1. Shown are Z-scores for each pathway (significance based on x < −2 or x > 2).

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