Fig. 9 | Scientific Reports

Fig. 9

From: Pipeline for development of acylated peptide based CGRP receptor antagonist with extended half-life for migraine treatment

Fig. 9

cAMP inhibition curves of hαCGRP8-37N25K-C20DA-γGlu and hαCGRP8-37A36S, N25K-C20DA-γGlu. CHO-K1 cells expressing the hCGRP-R were exposed to increasing concentrations of antagonist and a fixed concentration of hαCGRP corresponding to its EC90 (24 pM). Experiments were performed in singlicates. Data points are presented as mean ± range of n = 5. IC50 values are presented in figure legends as mean ± range.

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