Table 4 Summary of the outcomes of meta-analysis by random-effect model.

From: The effect of fecal bile acids on the incidence and risk-stratification of colorectal cancer: an updated systematic review and meta-analysis

 

Measured BAs

Number of studies

Heterogeneity (I2%, P-value)

SMD [95% CI]

P-value

CRC risk

CA

7

50, 0.06

0.41 [0.05, 0.76]

0.02

CDCA

7

15, 0.32

0.35 [0.09, 0.62]

0.009

DCA

9

54, 0.03

0.33 [0.03, 0.64]

0.03

LCA

8

74, 0.0004

0.31 [− 0.12, 0.75]

0.16

UDCA

4

0, 0.64

0.46 [0.14, 0.78]

0.005

Combined of BAs*

9

50, 0.0006

0.36 [0.21, 0.51]

< 0.00001

PBAs

3

0, 0.94

0.44 [0.09, 0.79]

0.01

SBAs

3

0, 0.52

− 0.06 [− 0.40, 0.29]

0.75

Combined of PBAs and SBAs

3

6, 0.38

0.19 [− 0.06, 0.45]

0.14

Total BAs

4

0, 0.57

0.27 [− 0.04, 0.57]

0.08

CRC incidence

CA

2

0,0.86

0.42 [0.04, 0.80]

0.03

CDCA

3

0, 0.62

0.61 [0.26, 0.96]

0.0007

DCA

5

83, 0.0001

0.18 [− 0.43, 0.79]

0.56

LCA

5

86, < 0.00001

0.46 [− 0.27, 1.19]

0.22

UDCA

1

–

0.10 [− 0.49, 0.70]

0.73

Combined of BAs*

5

75, < 0.00001

0.39 [0.09, 0.68]

0.01

PBAs

2

39, 0.20

0.33 [− 0.31, 0.97]

0.31

SBAs

2

0, 0.78

− 0.38 [− 0.86, 0.10]

0.12

Combined of PBAs and SBAs

2

44, 0.15

− 0.03 [− 0.49, 0.44]

0.90

Total BAs

8

89, < 0.00001

0.22 [− 0.41, 0.86]

0.49

  1. CA Cholic acid, CDCA Chenodeoxycholic acid, DCA Deoxycholic acid, LCA Lithocholic acid, UDCA Ursodeoxycholic acid, PBAs Primary bile acids, SBAs Secondary bile acids.
  2. *BAs included CA, CDCA, DCA, LCA, and UDCA.
Back to article page