Table 5 Summary of the outcomes of the meta-analysis by fixed-effect model.

From: The effect of fecal bile acids on the incidence and risk-stratification of colorectal cancer: an updated systematic review and meta-analysis

 

Measured BAs

Number of studies

Heterogeneity (I2%, P-value)

SMD [95% CI]

P-value

CRC risk

CDCA

7

15, 0.32

0.34 [0.10, 0.58]

0.005

UDCA

4

0, 0.64

0.46 [0.14, 0.78]

0.005

PBAs

3

0, 0.94

0.44 [0.09, 0.79]

0.01

SBAs

3

0, 0.52

− 0.06 [− 0.40, 0.29]

0.13

Combined of PBAs and SBAs

3

6, 0.38

0.19 [− 0.06, 0.43]

0.38

Total BAs

4

0, 0.57

0.27 [− 0.04, 0.57]

0.08

CRC incidence

CA

2

0, 0.86

0.42 [0.04, 0.80]

0.03

CDCA

3

0, 0.62

0.61 [0.26, 0.96]

0.0007

PBAs

2

39, 0.20

0.29 [− 0.20, 0.77]

0.24

SBAs

2

0, 0.78

− 0.38 [− 0.86, 0.10]

0.12

Combined of PBAs and SBAs

2

44, 0.15

− 0.05 [− 0.39, 0.29]

0.79

  1. CA Cholic acid, CDCA Chenodeoxycholic acid, DCA Deoxycholic acid, LCA Lithocholic acid, UDCA Ursodeoxycholic acid, PBAs Primary bile acids, SBAs Secondary bile acids.
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