Fig. 6 | Scientific Reports

Fig. 6

From: Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer

Fig. 6

Working model. Chemotherapy treatment of TNBC selects for cells with high or induced IMPDH2 expression. The resulting chemo-resistant cells possess high GTP levels and increased pro-tumorigenic phenotypes but are exquisitely sensitive to iMPDH2 inhibition. Figure partly created in BioRender (https://BioRender.com Bianchi-Smiraglia, A. (2025) https://BioRender.com/q21s162).

Back to article page