Table 1 The effects of LDLR knockdown on the body in aging mice.

From: The role of gut microbiota on skeletal muscle strength in LDLR knockdown aging mice

 

Acon (n = 12)

ALKd (n = 11)

Ocon (n = 6)

OLKd (n = 9)

Body weight (g)

26.92 ± 0.80

29.16 ± 0.66

30.33 ± 0.68

30.12 ± 0.47

Blood glucose (mmol/L)

13.11 ± 0.67

17.29 ± 1.18*

9.83 ± 0.84*ǂ

10.35 ± 1.21ǂ

Total cholesterol (mmol/L)

1.94 ± 0.09

2.01 ± 0.08

1.75 ± 0.27

1.37 ± 0.11*ǂ†

Triglycerides (mmol/L)

1.04 ± 0.18

0.90 ± 0.14

0.74 ± 0.14

0.35 ± 0.07*ǂ†

LDL-C (mmol/L)

0.38 ± 0.04

0.33 ± 0.04

0.27 ± 0.02*

0.22 ± 0.02*ǂ

HDL-C (mmol/L)

1.96 ± 0.14

2.27 ± 0.09

2.06 ± 0.31

1.53 ± 0.14ǂ

Glucose/LDL-C

38.27 ± 4.48

56.48 ± 4.13*

38.11 ± 4.70ǂ

48.65 ± 5.23

Grip strength (g)

67.72 ± 1.31

70.20 ± 2.42

60.33 ± 3.10*ǂ

70.00 ± 1.96†

Limb grip (g)

120.80 ± 2.67

128.80 ± 3.50

122.50 ± 4.32

129.70 ± 6.68

Limb suspension time (s)

48.60 ± 13.32

69.70 ± 9.56

16.17 ± 4.21*ǂ

14.33 ± 2.31*ǂ

  1. Data are reported as mean ± SEM. Two-tailed Student’s t-test or Mann–Whitney U test was used for the comparisons between two groups, and one-way analysis of variance (ANOVA) or the Kruskal-Wallis test was used for the comparisons between multiple groups. *p < 0.05 vs. Acon group, ǂp < 0.05 vs. ALKd group, †p < 0.05 vs. Ocon group. Acon Adult mice with empty vector, ALKd adult mice with LDLR knockdown, Ocon old mice with empty vector, OLKd old mice with LDLR knockdown, LDL-C low density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol.
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