Fig. 2
From: Preterm birth increases susceptibility to hyperglycemia induced glomerular alterations in male mice
Dual exposure to preterm birth and hyperglycemia results in transcriptional alterations in the kidney. Hierarchical clustering analysis of RNA-Seq data reveal the expression profiles clustering into four groups (a). A principal component analysis also showed clear dissociations between the expression profiles in all groups (b). Differentially expressed genes (DEGs) between preterm diabetic and term diabetic groups reveal differences in gene expression connected to the kidney vascularization, including renin (c). There were fewer renin positive glomeruli in the preterm diabetic group compared to term diabetic group (d, e).
