Table 1 Genotype and allelic frequency distribution across different models of inheritance of Notch1-4 in cases compared to controls.
From: Role of Notch gene receptors as prognostic biomarkers in colorectal cancer
Model | Genotype | Cases (n = 103) | Controls (n = 103) | OR (95% CI) | p |
|---|---|---|---|---|---|
Notch 1 (rs3124591) | |||||
Codominant | C/C | 54 (52.4%) | 39 (37.9%) | 1.00 | 0.0002 |
C/T | 42 (40.8%) | 64 (62.1%) | 2.11 (1.20–3.72) | ||
T/T | 7 (6.8%) | 0 (0%) | 0.00 (0.00-NA) | ||
Dominant | C/C | 54 (52.4%) | 39 (37.9%) | 1.00 | 0.035 |
C/T-T/T | 49 (47.6%) | 64 (62.1%) | 1.81 (1.04–3.15) | ||
Recessive | C/C–C/T | 96 (93.2%) | 103 (100%) | 1.00 | 0.0016 |
T/T | 7 (6.8%) | 0 (0%) | 0.00 (0.00-NA) | ||
Overdominant | C/C-T/T | 61 (59.2%) | 39 (37.9%) | 1.00 | 0.0021 |
C/T | 42 (40.8%) | 64 (62.1%) | 2.38 (1.36–4.17) | ||
Allele | CT | 150 (72.82) 56 (27.58) | 142 (68.93) 64 (31.07) | 1.000.828 (0.541–1.268) | 0.385 |
Log-additive | – | – | – | 1.28 (0.79–2.10) | 0.32 |
Notch 3 SNP (rs1043994) | |||||
Codominant | A/A | 69 (67%) | 80 (77.7%) | 1.00 | 0.2 |
A/G | 26 (25.2%) | 19 (18.4%) | 0.63 (0.32–1.24) | ||
G/G | 8 (7.8%) | 4 (3.9%) | 0.43 (0.12–1.49) | ||
Dominant | A/A | 69 (67%) | 80 (77.7%) | 1.00 | 0.086 |
A/G-G/G | 34 (33%) | 23 (22.3%) | 0.58 (0.31–1.08) | ||
Recessive | A/A-A/G | 95 (92.2%) | 99 (96.1%) | 1.00 | 0.23 |
G/G | 8 (7.8%) | 4 (3.9%) | 0.48 (0.14–1.65) | ||
Overdominant | A/A-G/G | 77 (74.8%) | 84 (81.5%) | 1.00 | 0.24 |
A/G | 26 (25.2%) | 19 (18.4%) | 0.67 (0.34–1.31) | ||
Allele | AG | 164 (79.62) 42 (20.38) | 179 (86.90) 27 (13.10) | 1.00 1.697 (1.001–2.873) | 0.049 |
Log-additive | – | – | – | 0.64 (0.40–1.05) | 0.071 |
Notch 4 SNP (rs367398) | |||||
Codominant | C/C | 58 (56.3%) | 64 (62.1%) | 1.00 | 0.67 |
C/T | 37 (35.9%) | 33 (32%) | 0.81 (0.45–1.46) | ||
T/T | 8 (7.8%) | 6 (5.8%) | 0.68 (0.22–2.08) | ||
Dominant | C/C | 58 (56.3%) | 64 (62.1%) | 1.00 | 0.39 |
C/T-T/T | 45 (43.7%) | 39 (37.9%) | 0.79 (0.45–1.37) | ||
Recessive | C/C–C/T | 95 (92.2%) | 97 (94.2%) | 1.00 | 0.58 |
T/T | 8 (7.8%) | 6 (5.8%) | 0.73 (0.25–2.20) | ||
Overdominant | C/C-T/T | 66 (64.1%) | 70 (68%) | 1.00 | 0.56 |
C/T | 37 (35.9%) | 33 (32%) | 0.84 (0.47–1.50) | ||
Allele | CT | 153 (74.27) 53 (25.72) | 161 (78.15) 45 (21.84) | 1.00 1.043 (0.647–1.681) | 0.862 |
Log-additive | – | – | – | 0.82 (0.52–1.27) | 0.37 |
