Table 1 Content of collagen I/III and inflammatory factors in lung tissue (\(\overline{x}\pm \text{s}\), n = 6).

From: IL-17A regulates airway remodelling in COPD through the PI3K/AKT/mTOR pathway

Groups

Ad-LacZ

Ad-LacZ+3MA

Ad-IL-1β

Ad-IL-1β+3MA

Collagen I/GAPDH

0.42 ± 0.17

0.57 ± 0.18

0.67 ± 0.22*

0.77 ± 0.13*#

Collagen III/GAPDH

0.83 ± 0.07

1.08 ± 0.26*

1.13 ± 0.28*

1.30 ± 0.20*#

IL-17A(pg/ml) by ELISA

449.1 ± 19.58

307.5 ± 36.45*

694.6 ± 24.00*

631.6 ± 80.92

IL-17A(%Area)by IHC

25.51 ± 2.27

20.46 ± 1.87*

32.67 ± 3.42*

25.80 ± 1.98

IL-6(pg/ml) by ELISA

468.10 ± 20.93

443.60 ± 23.15

891.20 ± 39.24*

780.30 ± 37.29*

CCL20(pg/ml) by ELISA in Lung

36.22 ± 8.17

31.82 ± 6.47

224.20 ± 21.56*

183.30 ± 10.29*

CCL20(pg/ml) by ELISA in plasma

27.66 ± 7.90

23.72 ± 3.84

137.10 ± 18.39*

64.19 ± 12.54*

  1. *P < 0.05 compared with Ad-LacZ group, #P < 0.05 compared with Ad-LacZ+3MA group.