Table 2 MR analysis results for the association between gut microbiota and cervical cancer lesion progression.
From: Dynamic causal effects of gut microbiota on cervical Cancer lesion progression
Gut microbiota (exposure) | Phenotype (outcome) | Method | Number of SNPs | p-value | OR | 95%CI |
|---|---|---|---|---|---|---|
class.Bacteroidia | HPV E7 Type 18 | IVW | 2 | 2.44 × 10−2 | 4.37 | 1.209–15.783 |
class.Coriobacteriia | HPV E7 Type 18 | IVW | 5 | 2.65 × 10−3 | 0.30 | 0.137–0.658 |
family.Coriobacteriaceae | HPV E7 Type 18 | IVW | 5 | 2.65 × 10−3 | 0.30 | 0.137–0.658 |
genus.Eubacteriumfissicatenagroup | HPV E7 Type 18 | IVW | 2 | 3.43 × 10−2 | 1.91 | 1.049–3.486 |
genus.Bilophila | HPV E7 Type 18 | IVW | 2 | 4.00 × 10−2 | 3.12 | 1.053–9.252 |
genus.Faecalibacterium | HPV E7 Type 18 | IVW | 3 | 7.04 × 10−3 | 3.56 | 1.414–8.969 |
order.Bacteroidales | HPV E7 Type 18 | IVW | 2 | 2.44 × 10−2 | 4.37 | 1.209–15.783 |
order.Coriobacteriales | HPV E7 Type 18 | IVW | 5 | 2.65 × 10−3 | 0.30 | 0.137–0.658 |
phylum.Bacteroidetes | HPV E7 Type 18 | IVW | 2 | 2.40 × 10−2 | 4.41 | 1.215–15.997 |
genus.Adlercreutzia | HPV E7 Type 18 | Wald ratio | 1 | 1.13 × 10−2 | 4.40 | 1.398–13.864 |
genus.Dorea | HPV E7 Type 18 | Wald ratio | 1 | 4.88 × 10−3 | 10.91 | 2.066–57.589 |
genus.Lactobacillus | HPV E7 Type 18 | Wald ratio | 1 | 1.33 × 10−2 | 4.09 | 1.34–12.464 |
genus.Ruminococcusgnavusgroup | HPV E7 Type 16 | IVW | 2 | 4.59 × 10−2 | 0.48 | 0.233–0.987 |
family.Porphyromonadaceae | HPV E7 Type 16 | Wald ratio | 1 | 2.61 × 10−2 | 0.12 | 0.019–0.78 |
genus.Adlercreutzia | HPV E7 Type 16 | Wald ratio | 1 | 1.57 × 10−2 | 4.12 | 1.306–13.019 |
genus.Marvinbryantia | HPV E7 Type 16 | Wald ratio | 1 | 2.27 × 10−2 | 0.20 | 0.051–0.799 |
genus.Eubacteriumventriosumgroup | CIN | IVW | 13 | 9.65 × 10−3 | 1.55 | 1.112–2.158 |
genus.Ruminococcustorquesgroup | CIN | IVW | 9 | 4.35 × 10−2 | 1.50 | 1.012–2.221 |
genus.Anaerostipes | CIN | IVW | 11 | 2.17 × 10−2 | 1.56 | 1.068–2.292 |
genus.Escherichia.Shigella | CIN | IVW | 9 | 4.87 × 10−2 | 0.68 | 0.466–0.998 |
genus.Faecalibacterium | CIN | IVW | 10 | 8.70 × 10−3 | 1.56 | 1.119–2.171 |
genus.Lachnospira | CIN | IVW | 6 | 1.22 × 10−2 | 0.52 | 0.313–0.868 |
genus.Ruminiclostridium5 | CIN | IVW | 10 | 6.35 × 10−3 | 1.79 | 1.178–2.708 |
genus.Paraprevotella | CIN | IVW | 12 | 2.11 × 10−2 | 1.34 | 1.045–1.73 |
family.Defluviitaleaceae | CC | IVW | 11 | 3.23 × 10−2 | 0.46 | 0.231–0.937 |
genus.Eubacteriumventriosumgroup | CC | IVW | 13 | 1.05 × 10−2 | 3.25 | 1.317–8.001 |
genus.Intestinimonas | CC | IVW | 17 | 9.57 × 10−3 | 2.34 | 1.23–4.438 |
genus.LachnospiraceaeNC2004 group | CC | IVW | 9 | 3.22 × 10−2 | 2.17 | 1.068–4.428 |
genus.RuminococcaceaeUCG003 | CC | IVW | 12 | 1.41 × 10−3 | 4.18 | 1.738–10.066 |
genus.RuminococcaceaeUCG011 | CC | IVW | 7 | 6.30 × 10−3 | 0.43 | 0.238–0.79 |
genus.DefluviitaleaceaeUCG011 | CC | IVW | 8 | 2.25 × 10−2 | 0.40 | 0.178–0.877 |
