Table 1 Characteristics of genes of interest obtained from the Euretos-based search, ranked by T/N ratio in TCGA.
Potential target | Predicted location | T/N ratio (TCGA) | TPM PDAC (TCGA) | TPM Panc (TCGA) | PE Panc | PE Duo | PE Liver | 3D crystal structure |
|---|---|---|---|---|---|---|---|---|
CEACAM5 | Membrane | 353.2 | 257.8 | 0.7 | ND | ND | Low | Yes |
MUCL3 | Membrane/cytoplasm | 152.0 | 57.8 | 0.4 | ND | ND | ND | No |
TMPRSS4 | Membrane/intracellular | 131.0 | 72.1 | 0.6 | Medium | Medium | Low | No |
COL17A1 | Cell junction, desmosome, membrane | 96.8 | 78.4 | 0.8 | ND | ND | ND | No |
MSLN | Membrane | 67.5 | 272.7 | 4.0 | ND | ND | ND | No |
CLDN18 | Membrane | 64.4 | 133.3 | 2.1 | ND | ND | ND | No |
PSCA | Membrane | 51.8 | 135.2 | 2.6 | Low | ND | ND | No |
AQP5 | Membrane, cytoplasmic vesicle membrane | 37.9 | 68.9 | 1.8 | Low | Low | Low | Yes |
VSIG2 | Membrane | 18.9 | 159.0 | 8.4 | High | High | Medium | No |
FXYD3 | Membrane | 17.4 | 236.8 | 13.6 | ND | Medium | ND | No |
GJB3 | Membrane, cell junction | 9.3 | 56.0 | 6.0 | ND | ND | ND | No |
