Table 3 Comparison of neurosteroid availability and levels between pituitary adenoma and normal tissue.

From: Comparative analysis of neurosteroid levels in normal and adenomatous human pituitary tissue

 

PA (n = 74)

NPT (n = 19)

p

PREG

Availability*

41(55%)

19 (100%)

< 0.001

Level**

89.5 [12.6-184.7]

7.2 [3.1–15.6]

< 0.001

7αOHPREG

Availability*

53 (72%)

19 (100%)

0.008

Level**

46.4 [15.2-125.3]

16.2 [7.5–24.1]

0.004

17OHPREG

–

–

–

DHEA

Availability*

59 (80%)

14 (74%)

0.6

Level**

11.1 [5.7–25.7]

9.9 [6.2–14.7]

0.6

DHEAS

   

Availability*

73 (99%)

19 (100%)

0.6

Level**

26.9 [10.1–53.4]

152.3 [83.6-210.8]

< 0.001

AE

Availability*

39(53%)

19(100%)

< 0.001

Level**

0.9 [0.4–1.7]

1 [0.5–1.7]

0.7

T

Availability*

40 (54%)

19 (100%)

< 0.001

Level**

0.8 [0.5–1.4]

1.2 [0.5–1.7]

0.5

DHT

Availability*

4 (5%)

10 (53%)

< 0.001

Level**

39.5 [1.2–93.8]

0.7 [0.6–0.8]

0.1

E2

-

-

-

Androsterone

Availability

42(58%)

18 (95%)

0.002

Level**

14.8 [3.2–34.3]

4.5 [2.4–5.9]

0.007

PRG

Availability*

7 (10%)

15 (79%)

< 0.001

Level**

0.9 [0.5–5.3]

0.4 [0.2–0.6]

0.04

ALLO

Availability*

1 (1%)

-

-

Level**

148.5

  

DOC

Availability*

22 (30%)

8 (42%)

0.3

Level**

0.5 [0.4–0.9]

0.4 [0.2–0.6]

0.2

Corticosterone

Availability*

15 (20%)

19 (100%)

< 0.001

Level**

0.9 [0.6–4.1]

13.2 [1.4–17.6]

0.01

Aldosterone

Availability*

2 (3%)

5 (26%)

0.001

Level**

0.7 [0.4-]

0.4 [0.3–1.1]

0.9

17OHPRG

Availability*

14 (19%)

16 (84%)

< 0.001

Level**

0.8 [0.5–1.7]

0.3 [0.1–1.1]

0.007

11 Deoxycortisol

Availability*

74 (100%)

19 (100%)

 

Level**

1.2 [0.8–2.8]

1.3 [0.5–2.5]

0.5

Cortisol

Availability*

70 (96%)

19 (100%)

0.4

Level**

6 [2.6–10.4]

56.5 [9.7–88.3]

< 0.001

  1. Statistically significant p values are shown in bold * n (%) ** ng/g, Levels presented as median and interquartile range [IQR] PA-Pituitary adenoma, NPT-Normal pituitary tissue, PREG-Pregnenolone, 7αOHPREG- 7α-Hydroxypregnenolone, 17OHPREG-17-Hydroxypregnenolone, DHEA- Dehydroepiandrosterone, DHEAS Dehydroepiandrosterone sulfate, AE-4-Androstene 3,17-dione, T-Testosterone, DHT-Dihydrotestosterone, E2- Estradiol, PRG-Progesterone, ALLO-Allopregnanolone, DOC-11deoxycorticosterone, 17OHPRG-17Hydroxyprogesterone.
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