Fig. 1
From: TLR4 deficiency does not alter glaucomatous progression in a mouse model of chronic glaucoma
Tlr4 deficiency does not influence the iris disease or the IOP phenotype of DBA/2J mice. (A) Representative slit-lamp images of Tlr4+/+ (wild-type DBA/2J) and Tlr4−/− eyes at 4, 8, and 12 months. The top row shows broad beam illumination, and the bottom row shows transillumination. The glaucoma-related changes in Tlr4−/− mice developed at the same time as in Tlr4+/+ mice. At 4 months of age, iris disease is not yet evident in either of the groups. Eight-month-old Tlr4+/+ and Tlr4−/− eyes present dispersed pigment and transillumination defects, which become more severe at 12 months of age. N > 20 mice per genotype at each age. (B) IOP distributions at key ages. There was no significant effect of the genotype on IOP levels at any age (two-way ANOVA; P = 0.702).
