Fig. 2
From: TLR4 deficiency does not alter glaucomatous progression in a mouse model of chronic glaucoma
Lack of Tlr4 does not affect glaucomatous neurodegeneration. (A) Representative images of nerves with no glaucoma (NOE, no/early, see Methods), moderate (MOD), and severe (SEV) damage. Scale bar = 10 μm. (B) Frequency distribution of optic nerve damage at 10.5 and 12 months of age. No significant differences were observed between the two genotypes of mice at any age (Fisher’s test at 10.5 months, P = 0.749; P = 0.169 at 12 months of age). (C) RGC layer cell counts for eyes with no glaucoma (NOE, both genotypes combined) or severe (SEV, split by genotype) glaucoma based on optic nerve damage. No significant differences in RGC layer cell numbers were observed between eyes of either genotype with severe glaucoma, indicating that somal and axonal damage are not uncoupled by the Tlr4 mutation (one-way ANOVA and post hoc Tukey’s HSD test, Tlr4+/+ SEV vs. Tlr4−/− SEV; P = 0.384). (D) Representative images of the retinas of Tlr4+/+ and Tlr4−/− mice with no or severe nerve damage at 40X. Scale bar = 50 μm.
